CCO Oncology Podcast

Congress to Clinic: Expert Takeaways on Emerging Data for MDS

Episode Summary

Audio podcast with key clinical highlights for myelodysplastic syndromes from the 2024 ASCO annual meeting and the EHA 2024 Congress. Listen to an expert analysis of new trial results with an emphasis on practical perspectives and summarizing the relevant clinically important takeaway points for everyday practice.

Episode Notes

In this episode, listen to Professor Courtney DiNardo, MD, MSCE, share her clinical highlights and clinical takeaways on new data for myelodysplastic syndromes (MDS) presented at the 2024 ASCO annual meeting and the  EHA 2024 Congress including:

• COMMANDS trial of luspatercept in transfusion-dependent, erythropoietin stimulating agent–naive, very low–, low- or intermediate-risk MDS
• Real-world dose-escalation and outcomes among patients with lower-risk MDS receiving luspatercept in clinical practice
• Phase II ASTREON trial―preliminary safety/efficacy of oral azacitidine in low-/intermediate, intermediate-risk, MDS
• Phase III IMerge: overall survival and transfusion independence with imetelstat in patients with low-risk or intermediate-1–risk MDS 
• Phase III ENHANCE study of magrolimab plus azacitidine vs azacitidine plus placebo for higher-risk MDS 
• Oral decitabine/cedazuridine plus venetoclax vs oral decitabine/cedazuridine alone in high-risk MDS: a propensity score analysis 

Program faculty:

Courtney DiNardo, MD, MSCE
Professor of Medicine
Department of Leukemia
MD Anderson Cancer Center
Houston, Texas

Brady L. Stein, MD, MHS
Professor of Medicine
Department of Hematology/Oncology
Northwestern University Feinberg School of Medicine
Chicago, Illinois

Eunice S. Wang, MD
Chief, Leukemia and Benign Hematology Service
Professor of Oncology
Roswell Park Comprehensive Cancer Center
Buffalo, New York

Resources:
To download the slides associated with this podcast discussion, please visit the program page.